Open AccessElaborating the Physiological Role of YAP as a Glucose Metabolism Regulator: A Systematic Review
Author(s) -
Ardo Sanjaya,
Hanna Goenawan,
Iwan Setiawan,
Julia Windi Gunadi,
Yenni Limyati,
Ronny Lesmana
Publication year - 2021
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.33594/000000359
Subject(s) - carbohydrate metabolism , glucose transporter , biology , glycolysis , gluconeogenesis , glucose uptake , metabolism , downregulation and upregulation , microbiology and biotechnology , effector , metabolic pathway , kinase , glucose metabolism disorder , pyruvate kinase , biochemistry , regulator , insulin , endocrinology , insulin resistance , gene
Yes-associated protein (YAP) is one of the Hippo pathway's two effectors, a pathway associated with organ size control. Research on YAP has focused on its oncogenic potential. However, in cancer cells, aside from inducing growth, YAP was also found to regulate glucose metabolism. Therefore, we aimed to explore YAP's control of glucose metabolism and whether these findings are translatable to physiological conditions. We conducted a systematic review of the MEDLINE database through PubMed in April 2020 and repeated the search in September 2020. We found that YAP induced the transcriptional activity of most genes associated with glucose metabolism from enzymes to transport proteins. In glycolysis and gluconeogenesis, YAP upregulated all enzymes except for enolase and pyruvate kinase. Multiple research has also shown YAP's ability to regulate the expression of glucose transporter of the GLUT family. Additionally, glucose concentration, hypoxia, and hormones such as insulin and glucagon regulate YAP activity and depend on YAP to exert their biological activity. In this review, we have shown that YAP is a central regulator of glucose metabolism, controlling both enzymes and proteins involved in glucose transport. YAP is also situated strategically in several pathways controlling glucose and was found to mediate their effects. If these results were consistent in physiological conditions and across glucose-associated metabolic disturbances, then YAP may become a prospective therapeutic target.