Open AccessMono- and Polyunsaturated Fatty Acids Counter Palmitate-Induced Mitochondrial Dysfunction in Rat Skeletal Muscle Cells
Author(s) -
Raid B. Nisr,
Dinesh S. Shah,
Harinder S. Hundal
Publication year - 2020
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.33594/000000282
Subject(s) - mitochondrial ros , mfn2 , proinflammatory cytokine , skeletal muscle , reactive oxygen species , mitochondrial biogenesis , polyunsaturated fatty acid , myogenesis , mitochondrion , biochemistry , medicine , chemistry , biology , endocrinology , microbiology and biotechnology , fatty acid , inflammation , mitochondrial fusion , mitochondrial dna , gene
Sustained increases in the circulating concentration of saturated fatty acids (SFAs, e.g. palmitate (PA), as seen during obesity, induces a chronic low grade inflammatory state that has been linked to metabolic dysfunction in tissues such as skeletal muscle that is characterized by disturbances in mitochondrial function and heightened production of reactive oxygen species (ROS). In contrast, monounsaturated (MUFAs, e.g. palmitoleate, PO; oleate, OL) and certain polyunsaturated (PUFAs, e.g. linoleate, LO) fatty acids have been shown to protect against some of the harmful metabolic effects induced by SFAs although it currently remains unknown whether this protection is associated with improved morphological and functional changes in mitochondrial biology and redox status in skeletal muscle cells. The aim of the present study was to investigate this issue.