Open AccessSUPT5H Post-Transcriptional Silencing Modulates PIN1 Expression, Inhibits Tumorigenicity, and Induces Apoptosis of Human Breast Cancer Cells
Author(s) -
Bilal Ahmad Lone,
Fawad Ahmad,
Shibendra Kumar Lal Karna,
Yuba Raj Pokharel
Publication year - 2020
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.33594/000000279
Subject(s) - gene silencing , pin1 , apoptosis , cancer research , breast cancer , cancer , biology , microbiology and biotechnology , chemistry , gene , genetics , isomerase
Breast cancer (BrCa) is one of the most common cancers and a highly heterogenous disease, both at the pathological and molecular levels. A common element for the progression of cancer is the presence of aberrant transcription. Targeting the misregulation of transcription may serve as a tool for cancer therapeutics. SUPT5H (Suppressor of Ty 5 homolog) is a highly conserved RNA polymerase II-associated transcription elongation and processivity factor. However, few studies have examined the relationship between SUPT5H and cancer.