Open AccessPKM2 Knockdown Induces Autophagic Cell Death via AKT/mTOR Pathway in Human Prostate Cancer Cells
Author(s) -
Prasanta Kumar Dey,
Amit Kundu,
Richa Sachan,
Jae Hyeon Park,
Mee Young Ahn,
Kyungsil Yoon,
Jaewon Lee,
Nam Deuk Kim,
In Su Kim,
Byung Mu Lee,
Hyung Sik Kim
Publication year - 2019
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.33594/000000107
Subject(s) - pkm2 , du145 , anaerobic glycolysis , viability assay , biology , gene knockdown , cancer cell , pyruvate kinase , cancer research , microbiology and biotechnology , cell , lncap , cancer , apoptosis , glycolysis , biochemistry , genetics , enzyme
Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis. Although high PKM2 expression is observed in various cancer tissues, its functional role in cancer metabolism is unclear. Here, we investigated the role of PKM2 in regulating autophagy and its associated pathways in prostate cancer cells.