Open AccessCurrent Paradigms to Explore the Gut Microbiota Linkage to Neurological Disorders
Author(s) -
Varruchi Sharma,
Atul Sankhyan,
Anshika Varshney,
Renuka Choudhary,
Anil Kumar Sharma
Publication year - 2020
Publication title -
european medical journal. neurology
Language(s) - English
Resource type - Journals
ISSN - 2054-4529
DOI - 10.33590/emjneurol/20-00068
Subject(s) - gut flora , synbiotics , gut–brain axis , microbiome , gut microbiome , neuroscience , biology , immune system , brain function , dysbiosis , bioinformatics , immunology , genetics , probiotic , bacteria
It has been suggested that an intricate communication link exists between the gut microbiota and the brain and its ability to modulate behaviour of an individual governing homeostasis. Metabolic activity of the microbiota is considered to be relatively constant in healthy individuals, despite differences in the composition of microbiota. The metabolites produced by gut microbiota and their homeostatic balance is often perturbed as a result of neurological complications. Therefore, it is of paramount importance to explore the link between gut microbiota and brain function and behaviour through neural, endocrine, and immune pathways. This current review focusses on the impact of altered gut microbiota on brain functions and how microbiome modulation by use of probiotics, prebiotics, and synbiotics might prove beneficial in the prevention and/or treatment of neurological disorders. It is important to carefully understand the complex mechanisms underlying the gut–brain axis so as to use the gut microbiota as a therapeutic intervention strategy for neurological disorders.