Open AccessDiscovery of small molecule bioactive agents from endophytic fungi of the Sonoran Desert
Author(s) -
B.P. Bashyal,
Anna M. Burns,
M.X. Liu,
P.A. Paranagama,
Christopher J. Seliga,
Thomas J. Turbyville,
E. M. Kithsiri Wijeratne,
Jianqian Zhan,
M.K. Gunathilaka,
A. Elizabeth Arnold,
Stanley H. Faeth,
L. Whittesell,
A.A.L. Gunathilaka
Publication year - 2007
Publication title -
grassland research and practice series
Language(s) - English
Resource type - Journals
eISSN - 2463-4751
pISSN - 0110-8581
DOI - 10.33584/rps.13.2006.3061
Subject(s) - plant use of endophytic fungi in defense , chaetomium globosum , fusarium oxysporum , chaetomium , fusarium , biology , biological activity , natural product , small molecule , cytotoxicity , hsp90 , microbiology and biotechnology , chemistry , biochemistry , botany , heat shock protein , in vitro , gene
In our search for novel small molecule bioactive agents from endophytic fungi of the Sonoran desert, extracts derived from cultures of some selected endophytic fungal strains have been screened in assays for inhibition of heat shock protein 90 (Hsp90) activity, cancer cell proliferation and migration. Chaetomium chiversii, Chaetomium globosum, Fusarium acuminatum and Fusarium oxysporum producing metabolites active in these assays were cultured on large-scale and the derived extracts were subjected to bioactivity-guided fractionation to obtain a variety of natural products with diverse structures, and potential applications in cancer chemotherapeutics. This paper discusses the isolation, characterisation, and biological activity of some selected small molecule metabolites. Keywords: endophytic fungi, small molecule natural products, isolation, structure elucidation biological activity, cytotoxic agents, cell migration inhibitors; Hsp90 inhibitors