CHRONIC KIDNEY DISEASE IN HEPATITIS B AND C PATIENTS: A SYSTEMATIC OVERVIEW

Developing countries like India face a unique challenge in managing disease like chronic kidney disease. Early detection and treatment is mandate to cope up with the renal failure and its comorbidities. In few of the cases development of hepatitis also occurs which further worsen the situation. Hepatitis being the blood borne virus affects the patient in most of the cases with renal failure. The advent of effective nucleotide analogs (NAs) has bid the chance to minimize the effects of hepatitis B virus (HBV) infection in HBV-positive patients with chronic kidney disease. Combination with immunosuppressive agents is most favorable in rapid renal function impairment. Other concern is the infection of hepatitis C virus (HCV). It represents a major medical and epidemiologic challenge in patients with renal replacement therapy with dialysis or transplantation. In this scenariothe presence of HCV correlates with higher rates of mortality than in HCVnegative subjects on dialysis or undergoing kidney transplant poses a major concern. Thus, the present review deals with the basics of CKD and its correlate with the hepatitis. Further we will also look into the effect of hemodialysis on hepatitis patients and their major