Open AccessPancreatic stellate cells - rising stars in pancreatic pathologies
Author(s) -
P Hrabák,
Marta Kalousová,
T Krechler,
T Zíma
Publication year - 2021
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.934783
Subject(s) - hepatic stellate cell , pancreatic cancer , pancreatitis , extracellular matrix , stroma , medicine , cancer research , induced pluripotent stem cell , fibrosis , pathology , biology , microbiology and biotechnology , cancer , embryonic stem cell , immunohistochemistry , gene , biochemistry
Pluripotent pancreatic stellate cells (PSCs) receive growinginterest in past decades. Two types of PSCs are recognized –vitamin A accumulating quiescent PSCs and activated PSCs- themain producents of extracellular matrix in pancreatic tissue. PSCsplays important role in pathogenesis of pancreatic fibrosis inpancreatic cancer and chronic pancreatitis. PSCs are intensivelystudied as potential therapeutical target because of theirimportant role in developing desmoplastic stroma in pancreaticcancer. There also exists evidence that PSC are involved in otherpathologies like type-2 diabetes mellitus. This article brings briefcharacteristics of PSCs and recent advances in research of thesecells.