Open AccessExercise Tolerance in Patients With Idiopathic Pulmonary Fibrosis, Effect of Supplemental Oxygen
Author(s) -
J Chlumský,
L Stehlík,
M Šterclová,
J Smetanová,
O Zindr
Publication year - 2022
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.934764
Subject(s) - dead space , medicine , ventilation (architecture) , inhalation , tidal volume , idiopathic pulmonary fibrosis , respiratory minute volume , pulmonary fibrosis , anesthesia , pulmonary rehabilitation , cardiology , respiratory system , fibrosis , mechanical ventilation , lung , pulmonary disease , mechanical engineering , engineering
Exercise tolerance in patients with idiopathic pulmonary fibrosis IPF is mainly limited by mechanical constrain of ventilation and high physiologic dead space. Oxygen enriched gas inhalation seems to increase ventilatory efficiency by reduction of dead space to tidal volume ratio (VD/VT) which probably mirrors improved pulmonary capillary flow and leads to longer physical tolerance at lower level of minute ventilation. The effect is noticeable at FIO2 that can be delivered in rehabilitation purposes or daily living activities.