Open AccessHeterogeneous Associative Plasticity in the Auditory Cortex Induced by Fear Learning – Novel Insight Into the Classical Conditioning Paradigm
Author(s) -
Ondřej Zelenka,
Ondřej Novák,
A Brunova,
Josef Syka
Publication year - 2021
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.934559
Subject(s) - classical conditioning , neuroscience , conditioning , auditory cortex , stimulus (psychology) , associative learning , psychology , fear conditioning , associative property , cognitive psychology , amygdala , mathematics , statistics , pure mathematics
We used two-photon calcium imaging with single-cell and cell-type resolution. Fear conditioning induced heterogeneous tuning shifts at single-cell level in the auditory cortex, with shifts both to CS+ frequency and to the control CS- stimulus frequency. We thus extend the view of simple expansion of CS+ tuned regions. Instead of conventional freezing reactions only, we observe selective orienting responses towards the conditioned stimuli. The orienting responses were often followed by escape behavior.