Open AccessRespiratory Function and Dysfunction in Parkinson-Type Neurodegeneration
Author(s) -
Michal Pokusa,
Dominika Hajduchova,
Tomáš Buday,
Alžbeta Trančiková
Publication year - 2020
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.934405
Subject(s) - neurodegeneration , respiratory system , pathological , disease , medicine , motor function , neuroscience , parkinson's disease , motor dysfunction , motor symptoms , intensive care medicine , physical medicine and rehabilitation , psychology , pathology
Parkinson's disease (PD) is most commonly manifested by the presence of motor symptoms. However, non-motor symptoms occur several years before the onset of motor symptoms themselves. Hallmarks of dysfunction of the respiratory system are still outside the main focus of interest, whether by clinicians or scientists, despite their indisputable contribution to the morbidity and mortality of patients suffering from PD. In addition, many of the respiratory symptoms are already present in the early stages of the disease and efforts to utilize these parameters in the early diagnosis of PD are now intensifying. Mechanisms that lead to the development and progression of respiratory symptoms are only partially understood. This review focuses mainly on the comparison of respiratory problems observed in clinical studies with available findings obtained from experimental animal models. It also explains pathological changes observed in non-neuronal tissues in subjects with PD.