Open AccessElectrospun nanofibers as support for the healing of intestinal anastomoses
Author(s) -
Martin Kralovič,
Michal Vjaclovský,
Andrea Kestlerová,
F. Rustichelli,
J Hoch,
Evžen Amler
Publication year - 2019
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.934387
Subject(s) - anastomosis , wound healing , nanofiber , complication , sepsis , surgery , medicine , regeneration (biology) , materials science , nanotechnology , microbiology and biotechnology , biology
The breakdown of intestinal anastomosis is a serious postsurgical complication. The worst complication is anastomotic leakage, resulting in contaminated peritoneal cavity, sepsis, multi-organ failure and even death. In problematic locations like the rectum, the leakage rate has not yet fallen below 10 %. Such a life-threatening condition is the result of impaired healing in the anastomotic wound. It is still vital to find innovative strategies and techniques in order to support regeneration of the anastomotic wound. This paper reviews the surgical techniques and biomaterials used, tested or published. Electrospun nanofibers are introduced as a novel and potential material in gastrointestinal surgery. Nanofibers possess several, unique, physical and chemical properties, that may effectively stimulate cell proliferation and collagen production; a key requirement for the healed intestinal wound.