Open AccessLaboratory options for risk assessment of pregnancy pathologies
Author(s) -
Andrea Kestlerová,
Ladislav Krofta,
A. Žufić,
K. Behavkova,
J. Račko,
Jiří Beneš,
Jaroslav Feyereisl
Publication year - 2019
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.934376
Subject(s) - preeclampsia , pathological , placental growth factor , medicine , pregnancy , obstetrics , fetus , pregnancy associated plasma protein a , first trimester , gynecology , biology , genetics
The most effective method of screening for chromosomal abnormalities and evaluating the risk of pregnancy pathologies in the first trimester is combined screening. The algorithm of screening is based on the combination of maternal age, measuring of the nuchal translucency and the fetal heart rate and analysis of the placental products of free ß-hCG and PAPP-A. For the screening of preeclampsia, placental growth factor (PlGF) is added. To distinguish between preeclampsia and other pathologies caused by placental dysfunction it is recommended to also extend the screening with selected immunological markers. We concluded that elevated biochemical and immunological markers can help to predict the threat of preeclampsia in the third trimester. Some markers can probably predict the development of particularly severe pathological conditions.