Open AccessSesame lignans increase sympathetic nerve activity and blood flow in rat skeletal muscles
Author(s) -
Katsuya Egawa,
Yuko Horii,
Yoshiko Misonou,
Izumi Yamasaki,
Daisuke Takemoto,
Yukiko Ono,
Tomohiro Rogi,
Hiroshi Shibata,
Katsuya omura
Publication year - 2020
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.934277
Subject(s) - blood flow , sympathetic nerve , skeletal muscle , sympathetic nervous system , autonomic nervous system , medicine , autonomic nerve , vagotomy , chemistry , endocrinology , laser doppler velocimetry , blood pressure , heart rate
Beneficial effects of sesame lignans, especially antioxidative effects, have been widely reported; however, its potential effects on autonomic nerves have not yet been investigated. Therefore, the current study aimed to investigate the effect of sesame lignans on the autonomic nervous system. The sympathetic nerve activity in rat skeletal muscle was measured using electrophysiological approaches, with blood flow determined using the laser Doppler method. Sesame lignans were administered intragastrically at 2 and 20 mg/kg, and after 60 min, the sympathetic nerve activity was observed to increase by 45.2 % and 66.1 %, respectively. A significant increase in blood flow (39.6 %) was also observed for the 20-mg/kg dose when measured at 55 min after administration. These sympathomimetic effects were completely prevented by subdiaphragmatic vagotomy, and the increase in blood flow was eliminated in the presence of the β2-adrenergic receptor inhibitor butoxamine. Thus, it is proposed that sesame lignans can increase the blood flow of skeletal muscle, possibly by exciting sympathetic nerve activity through the afferent vagal nerve.