Open AccessCoenzyme Q10 ameliorates cadmium induced reproductive toxicity in male rats
Author(s) -
Rinku Saha,
Shubhadeep Roychoudhury,
Kushal Kumar Kar,
Alex C. Varghese,
Parag Nandi,
Gita Sharma,
Grzegorz Formicki,
Petr Sláma,
Adriana Kolesárová
Publication year - 2019
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.934000
Subject(s) - coenzyme q10 , toxicity , oxidative stress , cadmium , sperm motility , reproductive toxicity , andrology , antioxidant , chemistry , semen quality , motility , semen , pharmacology , medicine , endocrinology , biology , biochemistry , genetics , organic chemistry
This study aimed at investigating the protective role of CoQ10 against cadmium (Cd)-induced reproductive toxicity in male rats. Adult male Wistar rats were exposed to an acute dose of Cd (25 mg/kg bwt; Cd group), Cd+CoQ10 (25 mg/kg bwt Cd+10 mg CoQ10; Cd-Q10 group) and distilled water (control) in vivo for 15 consecutive days and semen quality was assessed. A significant reduction was noted in sperm concentration, progressive motility, morphology and DNA integrity in both Cd- and Cd-Q10 groups in comparison to control indicating Cd-induced testicular lipid per oxidation (LPO) and decline in indigenous antioxidant defense system as measured by total antioxidant capacity (TAC) (p<0.05). However, simultaneous co-administration of CoQ10 along with Cd (Cd-Q10 group) was able to improve sperm concentration, motility, progressive motility, morphology, DNA integrity, and testicular TAC as well as lower LPO compared to Cd group (p<0.05). Results indicate that used dose of CoQ10 is capable of moderately ameliorating reproductive toxicity of Cd by improving semen quality and reducing testicular oxidative stress.