Open AccessPolymeric Nanogels as Drug Delivery Systems
Author(s) -
Jana Kousalová,
Tomáš Etrych
Publication year - 2018
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.933979
Subject(s) - drug delivery , nanotechnology , polymer , nanogel , materials science , nanoparticle , drug , self healing hydrogels , chemistry , pharmacology , polymer chemistry , organic chemistry , medicine
The present review focuses on the description of the design, synthesis and physico-chemical and biological evaluation of polymer nanogels. Nanogels are robust swollen cross-linked polymer nanoparticles that can be used as highly efficient and biodegradable carriers for the transport of drugs in controlled drug delivery. In this article, various types of nanogels are described and methods for their preparation discussed. The possibility of using synthesized nanosystems for targeting are reviewed to show the potential of tailored structures to reach either solid tumor tissue or direct tumor cells. Finally, the methods for encapsulation or attachment of biologically active molecules, e.g. drugs, proteins, are described and compared.