Open AccessDiabetes Converts Arterial Regulation by Perivascular Adipose Tissue From Relaxation Into H2O2-Mediated Contraction
Author(s) -
Radoslava Emilova,
Dimitrova Dz,
Mitko Mladenov,
Nikola HadziPetrushev,
Teodora Daneva,
P Padeshki,
Rudolf Schubert,
Mariela Chichova,
Lubomir T. Lubomirov,
Daniela Simeonovska-Nikolova,
Hristo Gagov
Publication year - 2016
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.933037
Subject(s) - contraction (grammar) , adipose tissue , medicine , endocrinology , skeletal muscle , chemistry , endothelium , muscle contraction , diabetes mellitus
This study aims to reveal the reason for the increased force of 5-hydroxytryptamine-induced contraction of endothelium-denuded skeletal muscle arteries of diabetic rats in the presence of perivascular adipose tissue (PVAT). Our data on rat gracilis arteries show that i) PVAT of skeletal muscle arteries of healthy and diabetic rats releases hydrogen peroxide (H2O2), ii) higher concentrations of 5-hydroxytryptamine increase the production of H2O2 in PVAT; iii) an enhanced PVAT production of H2O2 is the main, if not the only, reason for the sensitization of arterial contraction to 5-hydroxytriptamine-induced contraction in diabetes and iv) endothelium antagonizes the effect of PVAT-derived H2O2.