Open AccessThe effects of lidocaine on bupivacaine-induced cardiotoxicity in the isolated rat heart
Author(s) -
Ivo Křikava,
Jiří Jarkovský,
Petr Štourač,
Marie Novàkovâ,
Pavel Ševčík
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.932014
Subject(s) - bupivacaine , lidocaine , anesthesia , cardiotoxicity , local anesthetic , qrs complex , medicine , perfusion , blockade , heart rate , toxicity , blood pressure , cardiology , receptor
Bupivacaine is a widely used long-acting local anaesthetic. Inclinical practice, a mixture of bupivacaine and lidocaine is oftenused in order to combine the faster onset of sensory blockade oflidocaine with more profound and longer duration of blockade bybupivacaine. The aim of this study was to compare thecardiotoxicity of large doses of bupivacaine and mixture ofbupivacaine with lidocaine in the isolated rat heart and toestimate whether or not the addition of lidocaine in clinicallyrelevant concentration increases bupivacaine-induced toxicity.Experiments were performed on 21 adult male rats divided intothree groups: B (6 µg/ml bupivacaine), BL (6 µg/ml bupivacaineand 12 µg/ml lidocaine) and L (12 µg/ml lidocaine). Theexperiment consisted of three 30 min periods: stabilisation,perfusion and washout. The isolated hearts were perfusedaccording to Langendorff with Krebs-Henseleit solution atconstant pressure (80 mmHg) and 37 °C (CaCl2 1.25 mM) andthe heart rate (based on RR interval assessment), PQ and QRSintervals were measured. The present study shows that themixture of tested anaesthetics – bupivacaine and lidocaine –impairs the intraventricular conduction parameters (QRS intervalprolongation) to a lesser extent than bupivacaine itself, and thatthis effect is marked mainly at the beginning of perfusion.