Open AccessNew developments in septic acute kidney injury
Author(s) -
J Chvojka,
Roman Sýkora,
Thomas Karvunidis,
Jaroslav Raděj,
Aleš Kroužecký,
Ivan Novák,
Martin Matějovič
Publication year - 2010
Publication title -
physiological research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931936
Subject(s) - acute kidney injury , septic shock , sepsis , medicine , intensive care medicine , kidney , pathophysiology , organ dysfunction , shock (circulatory) , bioinformatics , biology
The kidney is a common "victim organ" of various insults in critically ill patients. Sepsis and septic shock are the dominant causes of acute kidney injury, accounting for nearly 50 % of episodes of acute renal failure. Despite our substantial progress in the understanding of mechanisms involved in septic acute kidney injury there is still a huge pool of questions preclusive of the development of effective therapeutic strategies. This review briefly summarizes our current knowledge of pathophysiological mechanisms of septic acute kidney injury focusing on hemodynamic alterations, peritubular dysfunction, role of inflammatory mediators and nitric oxide, mitochondrial dysfunction and structural changes. Role of proteomics, new promising laboratory method, is mentioned.