Open AccessCalretinin expression in the mammalian neocortex: a review
Author(s) -
Filip Barinka,
R Druga
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931930
Subject(s) - calretinin , neocortex , neuroscience , biology , neuroprotection , immunohistochemistry , immunology
In the mammalian neocortex, the calcium-binding proteincalretinin is expressed in a subset of cortical interneurons. In therecent years, research on interneurons is one of the most rapidlygrowing fields in neuroscience. This review summarizes theactual knowledge of the functions of calretinin in neuronalhomeostasis and particularly of the distribution, connectivity andphysiological properties of calretinin expressing interneurons inthe neocortex of rodents and primates, including humans. Thepossible neuroprotective role of calretinin and the presumed“resistance” of calretinin-expressing interneurons to variouspathological processes are also discussed.