Open AccessAnimal models in the study of exercise-induced cardiac hypertrophy
Author(s) -
Y Wang,
Ulrik Wisløff,
Ole Johan Kemi
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931928
Subject(s) - muscle hypertrophy , cardiac hypertrophy , treadmill , animal model , endurance training , aerobic exercise , exercise physiology , medicine , physical medicine and rehabilitation , neuroscience , computer science , cardiology , physical therapy , psychology
Exercise training-induced cardiac hypertrophy occurs following aprogram of aerobic endurance exercise training and it isconsidered as a physiologically beneficial adaptation. Toinvestigate the underlying biology of physiological hypertrophy,we rely on robust experimental models of exercise training inlaboratory animals that mimic the training response in humans.A number of experimental strategies have been established, suchas treadmill and voluntary wheel running and swim trainingmodels that all associate with cardiac growth. These approacheshave been applied to numerous animal models with variousbackgrounds. However, important differences exist betweenthese experimental approaches, which may affect theinterpretation of the results. Here, we review the variousapproaches that have been used to experimentally study exercisetraining-induced cardiac hypertrophy; including the advantagesand disadvantages of the various models.