Open AccessMyocardial phospholipid remodeling under different types of load imposed during early postnatal development
Author(s) -
František Novák,
František Kolář,
Blanka Hamplová,
Libor Mrnka,
V. Pelouch,
B Ošťádal,
Olga Nováková
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931924
Subject(s) - cardiolipin , pressure overload , medicine , microbiology and biotechnology , endocrinology , phospholipid , inner mitochondrial membrane , chemistry , mitochondrion , biology , membrane , muscle hypertrophy , biochemistry , cardiac hypertrophy
Normal increase in hemodynamic load during early postnatal lifeis associated with heart growth and maturation of membranestructures that is accompanied by remodeling of membraneprotein and lipid components. This review describes remodelingof phospholipids (PL) in rat myocardium during normal postnataldevelopment and during accelerated cardiac growth induced byadditional workload (aorta constriction, chronic hypoxia andhyperthyroidism) imposed on the heart early after birth. Normalphysiological load after birth stimulates the development ofmembrane structures and synthesis of PL. While hyperthyroidismaccelerates these processes, pressure overload has an inhibitoryeffect. These changes primarily influence the maturation ofmitochondrial membranes as cardiolipin is one of the mostaffected PL species. The most sensitive part of PL structure intheir remodeling process are PL acyl chains, particularlypolyunsaturated fatty acids that are the key componentsdetermining the basic physicochemical properties of themembrane bilayer and thus the function of membrane-boundproteins and membrane-derived signaling lipid molecules. It isevident that PL remodeling may significantly influence bothnormal and pathological postnatal development of myocardium.