Open AccessPlasma corticosterone, insulin and glucose changes induced by brief exposure to isoflurane, diethyl ether and CO2 in male rats
Author(s) -
Homeira Zardooz,
Fatemeh Rostamkhani,
Jala Zaringhalam,
Farzaneh Faraji Shahrivar
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931896
Subject(s) - corticosterone , isoflurane , endocrinology , medicine , insulin , anesthetic , diethyl ether , chemistry , hormone , anesthesia , chromatography , organic chemistry
The impact of anesthetic agents on endocrine and metabolicfactors is an important issue. The present study has comparedthe effects of a short-term exposure to diethyl ether, isoflurane,or CO2 on plasma corticosterone, insulin and glucoseconcentrations since the duration of anesthetic exposure mayhave an effect on those factors. Male rats were divided into fedand fasted groups. The experimental rats were briefly exposed todiethyl ether, isoflurane, or CO2 (the degree of anesthesia wasidentical), while a control group was not exposed to theanesthetics. In the fed rats, diethyl ether exposure increased thelevels of plasma glucose. CO2 exposure decreased plasmacorticosterone and increased plasma glucose levels. Isofluraneexposure caused no changes in plasma corticosterone, glucose,or insulin levels. In the fasted rats, diethyl ether exposureincreased plasma corticosterone and reduced plasma insulinlevels. The plasma corticosterone and insulin levels weresignificantly increased by CO2 exposure. Isoflurane exposuredecreased plasma insulin levels. A brief exposure to either diethylether or CO2 changed the plasma corticosterone, glucose, andinsulin levels in fed and/or fasted rats. However, isofluraneexposure had the least effect on the concentration of thesefactors in both the fed and fasted states.