Open AccessDifferential impact of acute bout of exercise on redox- and oxidative damage-related profiles between untrained subjects and amateur runners
Author(s) -
Stefano Falone,
Alessandro Mirabilio,
A Pennelli,
Marisa Cacchio,
Angela Di Baldassarre,
Sabina Gallina,
Anthony G. Passerini,
Fernanda Amicarelli
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931884
Subject(s) - oxidative stress , lipid peroxidation , hormesis , reactive oxygen species , aerobic exercise , population , antioxidant , stressor , medicine , exercise physiology , sports medicine , physical exercise , lipid oxidation , oxidative phosphorylation , physical therapy , physiology , chemistry , biochemistry , environmental health , clinical psychology
Despite the demonstrated exercise-induced increase in reactiveoxygen species (ROS) production, growing epidemiologicalevidence indicates that habitual, moderate physical activityreduces the incidence of several oxidative stress-based diseases.This apparent paradox can be explained taking into account thatROS produced during repeated exercise bouts may act as mildstressors able to trigger physiological and biomolecular hormeticresponses through a number of redox-sensitive transcriptionpathways. Unfortunately, much more limited information isavailable from general population-based research, which couldbetter reflect the condition of common people interested inachieving and maintaining good fitness levels. The present workaimed at investigating whether and how exercise-related habitsin non-professional regular runners (n=33) can affect thesystemic anti-oxidative capacity, and the resting serum levels oftypical lipid peroxidation-related by-products and oxidativelydamaged proteins, in comparison with untrained sedentaryindividuals (n=25). We also analyzed in both groups the redoxresponse elicited by a modified Bruce-based maximal exercisetest on the same parameters. Our findings indicated that longterm regular and moderate practice of aerobic physical activitycan increase antioxidant defense systems, lower the restingprotein oxidation processes and reduce the immediate upregulation of lipid-targeting oxidative stress in response to anacute bout of exercise.