Open AccessAntioxidants and vitamins in clinical conditions
Author(s) -
Z Zadák,
Radomı́r Hyšpler,
Alena Tichá,
Miloslav Hronek,
Petra Fikrová,
Jana Rathouska,
Dana Hrnčiariková,
Rudolf Štětina
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931861
Subject(s) - catalase , reactive oxygen species , antioxidant , carotenoid , uric acid , superoxide dismutase , chemistry , biochemistry , glutathione , glutathione peroxidase , enzyme
Various reactive oxygen species (ROS) may be produced fromnormal biochemical, essential metabolic processes or fromexternal sources as exposure to a variety of agents presented inthe environment. Lipids, proteins, carbohydrates and DNA are allcapable of reacting with ROS and can be implicated in etiology ofvarious human disorders (rheumatoid arthritis, reperfusion injury,atherosclerosis, lung diseases etc.). In the organism damage byROS is counteracted with natural antioxidants (glutathioneperoxidases, superoxide dismutases, catalase, glutathione,ubiquinol, uric acid, and essential minerals) and nutritionalantioxidants from diet (i.e. vitamins E, C, carotenoids). Possiblemechanisms of nutritional depletion and side effects of highintake are in the article described.