Open AccessActigenetic of ACE gene polymorphism in Czech obese sedentary females
Author(s) -
Pavel Suchánek,
Jaroslav Hubáček,
Ivana Králová Lesná,
V. Pinekerova,
Věra Adámková
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931859
Subject(s) - obesity , medicine , polymorphism (computer science) , genotype , angiotensin converting enzyme , endocrinology , abdominal obesity , candidate gene , metabolic syndrome , biology , gene , genetics , blood pressure
Obesity is a serious health problem worldwide and many geneshave been implicated in determination of obesity, but ourknowledge of the genes responsible for individual differences inweight loss after physical intervention are poor. One of thecandidate genes is a gene for angiotensin-converting enzyme(ACE) ant its insertion/deletion (I/D) polymorphism. We haveanalyzed the association between the ACE gene variant inintervened obese females. Twenty four unrelated healthy obese(BMI > 29.9 kg/m2, with abdominal type of obesity) premenopausal (age between 25 and 45 years) Czech Caucasian sedentary and non-diabetic females, pre-selected according the ACE I/D polymorphism (twelve II and twelve DD homozygotes)were studied in a medical research centre. They underwent 9weeks intervention program (combination of the lowering ofdietary intake to optimal level for the age and 3 times a weekphysical activity at fitness centre). The participants weresupervised to sustain a heart rate of 65 % of maximum.Anthropometrical, biochemical parameters and body composition(Bodystat 1500) were analyzed before and after the intervention.Our study suggest, that in Czech Caucasian females I/Dpolymorphism within the ACE gene will have no major effect onweight loss. Interestingly, we have detected, that in obesefemales II genotype was associated with higher increase in basalmetabolic rate (202 kcal per day) then in DD homozygotes(p<0.05), thus at least under some circumstances, this geneticvariant may have an slight effect on BMI development.