Open AccessLife style change and reverse cholesterol transport in obese women
Author(s) -
Ivana Králová Lesná,
Pavel Suchánek,
J. Kovář,
R. Poledne
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931856
Subject(s) - cholesterol , reverse cholesterol transport , randomized controlled trial , weight loss , apolipoprotein b , endocrinology , medicine , life style , obesity , lipoprotein , chemistry , environmental health
HDL cholesterol resp. apolipoprotein A1 concentrations are toolsto estimate individual CVD risk, although only a part of HDLparticles participate in reverse cholesterol transport (RCT). Thisdiscrepancy was analyzed in life style change based on increaseof physical activity and dietary counseling. Efflux of cholesterolfrom pre-labeled macrophages to plasma acceptors of testedindividuals was used as an RCT measure. Changes of lipoproteinparameters, glucose, fasting insulin concentrations and RCT wereanalyzed in 15 obese women after 9-week intervention consistedof 5 sessions of increased physical activity per week. Controlledincrease in physical activity for 9 weeks induced a decrease ofbody weight averaging 9 kg (ranged from 2.3 to 15.5 kg). Theintervention leads to significant decreases of triglycerides,apoprotein A1 and apoprotein B concentration, whereas totalcholesterol, LDL cholesterol and HDL cholesterol did not changesignificantly. The increase of RCT was not significant, but therewas highly significant negative correlation between individualdecrease of body weight and an increase of RCT. Significantincrease of RCT was found in 13 persons with a weight reductionmore than 3.5 kg. Substantial weight loss is necessary toincrease RCT.