Open AccessBrain-Derived Neurotrophic Factor Treatment Increases the Skeletal Muscle Glucose Transporter 4 Protein Expression in Mice
Author(s) -
Masataka Suwa,
Kenji Yamamoto,
Hiroshi Nakano,
Haruka Sasaki,
Zsolt Radák,
Shuzo Kumagai
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931784
Subject(s) - glut4 , skeletal muscle , endocrinology , medicine , brain derived neurotrophic factor , neurotrophic factors , gastrocnemius muscle , glucose transporter , hypophagia , chemistry , biology , insulin , body weight , receptor
The purpose of the present study was to investigate whetherperipheral brain-derived neurotrophic factor (BDNF) treatmentinduced metabolic adaptations in mouse skeletal muscle. BDNF(20 mg/kg/day) was injected subcutaneously for successive14 days. BDNF treatment significantly reduced the total foodintake and inhibited the weight gain in comparison to the controlgroup. The glucose transporter 4 (GLUT4) protein expression inthe gastrocnemius muscle was significantly increased by BDNFtreatment in comparison to the control and pair-fed groups.Neither the oxidative nor the glycolytic enzyme activities in thegastrocnemius muscle changed after the BDNF treatment. Theseresults suggest that the peripheral BDNF treatment promotes theskeletal muscle GLUT4 protein expression as well as hypophagia.