Open Access[3H]SCH 23390 binding in various brain regions of C57BL/6J mice with repeated experience of victory or social defeat in agonistic interactions
Author(s) -
Д. Ф. Августинович,
Olga V. Alekseyenko
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931779
Subject(s) - agonistic behaviour , victory , sch 23390 , striatum , cortex (anatomy) , medicine , amygdala , endocrinology , frontal cortex , chemistry , antagonist , psychology , neuroscience , biology , receptor , dopamine , aggression , developmental psychology , political science , politics , law
The binding of [3H]SCH 23390 has been studied in various brainregions of male mice with the experience of repeated victory(winners) or defeat (losers) gained over 10 (T10) and 20 (T20)days of daily agonistic confrontations. In the frontal cortex, Bmaxof [3H]SCH 23390 binding sites was found to be increased in T10losers and decreased in T20 losers when compared to the controlmice. In the striatum, T10 and T20 winners had reduced valuesof [3H]SCH 23390 binding sites than the ones in the control mice.The Kd was increased in the frontal cortex of T10 losers and T10winners as well as in the amygdala of T20 losers. Reduced Kdvalues were found in the striatum of all experimental groups aswell as in the amygdala of T20 winners. Thus, both specificchanges relating to social behavior patterns and non-specificones in [3H]SCH 23390 binding were found in the brain regionsof mice after 10 and 20 days of intermale confrontations.