Open AccessOsteogenic Cells on Bio-Inspired Materials for Bone Tissue Engineering
Author(s) -
Barbora Vagaská,
Lucie Bačáková,
Elena Filová,
K. Balík
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931776
Subject(s) - biocompatibility , bone tissue , materials science , tissue engineering , wetting , biomedical engineering , adhesion , nanotechnology , cell adhesion , bone cell , biomaterial , bone healing , polymer , chemistry , composite material , anatomy , microbiology and biotechnology , medicine , metallurgy , biology
This article reviews the development of artificial bone substitutesfrom their older single-phase forms to novel multi-phasecomposites, mimicking the composition and architecture ofnatural bone tissue. The new generation of bone implants shouldbe bioactive, i.e. they should induce the desired cellularresponses, leading to integration of the material into the naturaltissue and stimulating self-healing processes. Therefore, the firstpart of the review explains the common principles of the cellmaterial interaction and summarizes the strategies how toimprove the biocompatibility and bioactivity of the materials bymodifying the physico-chemical properties of the materialsurface, such as surface chemistry, wettability, electrical charge,rigidity, microroughness and especially nanoroughness. The latterhas been shown to stimulate preferentially the growth ofosteoblasts in comparison with other competitive cell types, suchas fibroblasts, which could prevent fibrous tissue formation uponimplantation. The second more specialized part of the reviewdeals with materials suitable for bone contact and substitution,particularly novel polymer-based composites reinforced withfibres or inorganic particles and containing bioactive components,such as crystals of hydroxyapatite or other calcium phosphates,synthetic ligands for cell adhesion receptors or growth factors.Moreover, if they are degradable, they can be gradually replacedwith a regenerating tissue.