Open AccessEffect of Short-Term Maximal Exercise on BNP Plasma Levels in Healthy Individuals
Author(s) -
J Krupicka,
Tomáš Janota,
Z Kasalová,
J Hradec
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931773
Subject(s) - medicine , heart failure , natriuretic peptide , cardiology , brain natriuretic peptide , heart rate , physical exercise , endocrinology , blood pressure
Many studies documented the relationship between elevatedplasma concentrations of natriuretic peptides and cardiovasculardiseases, especially heart failure. However, it is still uncertainwhether physical exercise leads to a significant release ofnatriuretic peptide in healthy subjects. The aim of this study wasto determine the effect of maximal physical activity on plasmaBNP concentrations in healthy individuals within 3 hours after theshort-term exercise. BNP plasma concentrations were measuredin 15 healthy volunteers before, immediately after as well as1 hour and 3 hours after bicycle spiroergometry. Maximalworkload and exercise capacity were assessed in watts, wattseconds, metabolic equivalents and VO2max. Mean BNP plasmalevels before, immediately after, 1 hour and 3 hours postexercise were 19.4±2.5; 30.6±4.7; 17.9±2.5 and 18.7±3.1pg/ml, respectively. The increase of BNP concentrationsimmediately after exercise was statistically significant (p=0.0017)compared to baseline values. We did not find any correlationbetween the post-exercise increase of BNP levels and age, bodymass index, maximal workload or exercise capacity. Inconclusion, short-term maximal physical exercise in healthyindividuals led to a fast and transient rise of plasma BNPconcentrations, which remained well within normal range and farbelow the cut-off value for heart failure (100 pg/ml).