Open AccessAnticonvulsant Action of a New Analogue of Allopregnanolone in Immature Rats
Author(s) -
Pavel Mareš,
Hana Kubová,
Alexander Kasal
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931754
Subject(s) - allopregnanolone , neuroactive steroid , pentylenetetrazol , anticonvulsant , pharmacology , drug , medicine , cannabidiol , steroid , epilepsy , gabaa receptor , cannabis , hormone , receptor , psychiatry
Neuroactive steroids represent potential antiepileptic drugs. Wetested a newly synthesized analogue of allopregnanolone 3αhydroxy-21ξ,22-oxido-21-homo-5α-pregnan-20-on (HOHP) against two types of pentylenetetrazol-induced seizures(100 mg/kg s.c.) in 12- and 25-day-old rats. Ganaxolone, a neuroactive steroid in clinical trials, served as a reference drug. Pretreatment with either steroid suppressed generalized tonicclonic seizures in both age groups, their efficacy was comparable.HOHP as well as ganaxolone were more active in 12- than in25-day-old rats (effective doses were 40 and 60 mg/kg,respectively). Minimal clonic seizures, which can be elicited onlyin 25-day-old rats, were not influenced by any drug. Very shortduration of anticonvulsant action of HPOP demonstrated in12-day-old animals indicates that this drug might be used only inacute treatment in epileptology.