Open AccessTotal Body Response to Mechanical Ventilation of Healthy Lungs: an Experimental Study in Piglets
Author(s) -
J Kobr,
Jiří Fremuth,
K Pizingerová,
S Fikrlová,
Petr Jehlička,
P Honomichl,
Lumír Šašek,
Jaroslav Ráček,
O Topolcan
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931752
Subject(s) - ventilation (architecture) , tidal volume , mechanical ventilation , medicine , renal function , creatinine , anesthesia , respiratory minute volume , lung , respiratory system , mechanical engineering , engineering
The objective of our study was to assess the influence ofmechanical ventilation on healthy body organs. Fifteen piglets(aged 6 weeks, 19-27 kg) were anesthetized, instrumented, anddivided into three groups: Group A – spontaneously breathing,group B – mechanically ventilated with tidal volume 6 ml/kg, andgroup C – ventilated with tidal volume 10 ml/kg for 12 hours. Theparameters of lung, heart, liver and kidney functionsneurohumoral regulation and systemic inflammatory reactionwere recorded initially (time-1) and after 12 hours (time-12) ofmechanical ventilation. At the onset of experiment (time-1) thelevels of soluble adhesive molecules were higher (CAM; P<0.01),glomerular filtration index and free water clearance were lower(P<0.05) in both ventilated groups than in group A. Rightventricle myocardial performance index was higher (RIMP;P<0.05) in group C when compared with group A. Levels of CAM(P<0.05) and creatinine clearance (P<0.01) were higher, freewater clearance was lower (P<0.05) in group C when comparedto group B. At time-12 the RIMP (P<0.05) and levels of CAMwere increased (P<0.01), creatinine clearance was decreased(P<0.05) in both ventilated groups compared to the sameparameter at time-1. Ventilation index was higher (P<0.05), andhypoxemic index was lower (P<0.01) in group C when comparedto group B. In conclusion, this study showed that mechanicalventilation induced changes compatible with early inflammatoryresponse in healthy animals. Higher tidal volumes haddetrimental effect on ventilatory parameters, reduced myocardialperformance and potentiated adverse reaction of other organs.