Open AccessECG Body Surface Mapping Changes in Type 1 Diabetic Patients with and without Autonomic Neuropathy
Author(s) -
Sabina Pálová,
Klaudia Szabó,
J Charvát,
J Slavíček,
Eva Medová,
Mikuláš Mlček,
O Kittnar
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931715
Subject(s) - medicine , repolarization , cardiology , qrs complex , diabetes mellitus , electrocardiography , qt interval , autonomic neuropathy , st segment , heart rate , endocrinology , blood pressure , myocardial infarction , electrophysiology , biology , cell culture , genetics , neuroblastoma
ECG body surface mapping (BSM) parameters in patients withdiabetes mellitus Type 1 (DM1) are significantly differentcomparing to healthy non-diabetic subjects. Hypothesis thatthese changes are more pronounced in DM1 patients withautonomic neuropathy (AN) was tested. The parameters of BSMwere registered by diagnostic system Cardiag 112.2 in 54 DM1patients including 25 with AN and 30 control subjects. AN wasdiagnosed according to Ewing criteria when two or more Ewingtests were abnormal. In classic 12-lead ECG the heart rate wasincreased, QRS and QT shortened (p<0.01) and QTC prolonged inDM1 patients. The VCG measurement of QRS-STT angles andspatial QRS-STT angle showed non-significant differences. Theabsolute values of maximum and minimum in depolarization andrepolarization isopotential, isointegral, isoarea maps weresignificantly different in DM1 patients in comparison with controls(p<0.01). The changes were more pronounced in DM1 patientswith AN than in DM patients without AN (p<0.05). The QTduration measured in 82 leads of thorax was significantlyshortened in 68 leads of both groups of DM 1 patients (p<0.01)when compared with controls. In 34 of them this shortening wasmore pronounced in DM1 patients with AN than in DM1 patientswithout AN (p<0.05). The results showed that the method ofECG BSM is capable to confirm the presence of autonomicneuropathy in diabetic patients.