Open AccessAntioxidant Status and Lipid Peroxidation in Diabetic Rats under Hyperbaric Oxygen Exposure
Author(s) -
Tokio Matsunami,
Yukita Sato,
Tadashi Satô,
Masayoshi Yukawa
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931711
Subject(s) - tbars , oxidative stress , lipid peroxidation , diabetes mellitus , reactive oxygen species , thiobarbituric acid , antioxidant , superoxide dismutase , medicine , endocrinology , chemistry , streptozotocin , pharmacology , biochemistry
Hyperglycemia is known to cause oxidative stress that leadsmainly to enhanced production of mitochondrial reactive oxygenspecies (ROS). It has been demonstrated that hyperbaric oxygen(HBO) treatment also increases the formation of ROS. There are,however, no comprehensive evaluations of such oxidative effectsin diabetes which requires HBO treatment. The purpose of thisstudy is to investigate the influence of a clinically-recommendedHBO treatment on glucose homeostasis and oxidative stress inrats with streptozotocin (STZ)-induced diabetes. Under theclinically-used HBO exposure protocol, the levels of bloodglucose, thiobarbituric acid reactive substances (TBARS) as a lipidperoxidation marker, and the activity of superoxide dismutase(SOD) as an antioxidant enzyme marker were investigated in theerythrocytes, liver, pancreas, skeletal muscle, and brain of ratswith STZ-induced diabetes. The levels of blood glucose andTBARS increased significantly (p<0.05), and the activity of SODdecreased significantly (p<0.05) in the erythrocytes and allorgans of rats with diabetes subjected to HBO exposure. Theseresults suggested that HBO exposure might boost glucoseautoxidation and increase ROS production in STZ-induceddiabetes as side-effects of administering HBO treatment for thefirst time.