Olfactory Bulbectomy Induced Oxidative and Cell Damage in Rat: Protective Effect of Melatonin | Zendy

Inmaculada Tasset | Zendy; Francisco Javier Medina Fernández | Zendy; José Peña | Zendy; Ignacio Jimena | Zendy; Marı́a Muñoz | Zendy; Manuel Salcedo | Zendy; Concepción Ruíz | Zendy; Montserrat Feijóo | Zendy; Pedro Montilla | Zendy; Isaac Túnez | Zendy

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Olfactory Bulbectomy Induced Oxidative and Cell Damage in Rat: Protective Effect of Melatonin

Author(s) -

Inmaculada Tasset,

Francisco Javier Medina Fernández,

José Peña,

Ignacio Jimena,

Marı́a Muñoz,

Manuel Salcedo,

Concepción Ruíz,

Montserrat Feijóo,

Pedro Montilla,

Isaac Túnez

Publication year - 2010

Publication title -

physiological research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.647

H-Index - 70

eISSN - 1802-9973

pISSN - 0862-8408

DOI - 10.33549/physiolres.931684

Subject(s) - melatonin , oxidative stress , medicine , endocrinology , lipid peroxidation , glutathione , oxidative damage , chemistry , biology , biochemistry , enzyme

In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damageprompted by bilaterally olfactory bulbectomy. Olfactorybulbectomy caused an increase in lipid peroxidation products andcaspase-3, whereas it prompted a decrease of reducedglutathione (GSH) content and antioxidative enzymes activities.Additionally, olfactory bulbectomy induced behavioral changescharacterized by the enhancement of immobility time in theforced swim test and hyperactivity in the open field test. All thesechanges were normalized by treatment of Mel (14 days). Ourdata show that Mel has a beneficial neuropsychiatric actionagainst oxidative stress, cell damage and behavior alterations.

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