Open AccessOlfactory Bulbectomy Induced Oxidative and Cell Damage in Rat: Protective Effect of Melatonin
Author(s) -
Inmaculada Tasset,
F Medina,
José Peña,
Ignacio Jimena,
María del Carmen Muñoz,
Manuel Salcedo,
Carmen García-Ruiz,
Montserrat Feijóo,
Pedro Montilla,
Isaac Túnez
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931684
Subject(s) - melatonin , oxidative stress , medicine , endocrinology , lipid peroxidation , glutathione , oxidative damage , chemistry , biology , biochemistry , enzyme
In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damageprompted by bilaterally olfactory bulbectomy. Olfactorybulbectomy caused an increase in lipid peroxidation products andcaspase-3, whereas it prompted a decrease of reducedglutathione (GSH) content and antioxidative enzymes activities.Additionally, olfactory bulbectomy induced behavioral changescharacterized by the enhancement of immobility time in theforced swim test and hyperactivity in the open field test. All thesechanges were normalized by treatment of Mel (14 days). Ourdata show that Mel has a beneficial neuropsychiatric actionagainst oxidative stress, cell damage and behavior alterations.