Open AccessSerum visfatin levels in patients with anorexia nervosa and bulimia nervosa
Author(s) -
I Dostálová,
D Sedlácková,
Hana Papežová,
J Nedvı́dková,
Martin Haluzı́k
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931680
Subject(s) - medicine , leptin , endocrinology , anorexia nervosa , bulimia nervosa , body mass index , obesity , adipose tissue , hormone , insulin , eating disorders , psychiatry
Visfatin is an adipose tissue-derived hormone shown to correlatewith visceral fat mass in patients with obesity. Its possible role inpatients with different types of eating disorders is unknown. Wemeasured fasting serum levels of visfatin and leptin andsurrogate measures of insulin sensitivity in 10 untreated patientswith anorexia nervosa (AN), 10 untreated patients with bulimianervosa (BN) and 20 age-matched healthy women (C) to studythe possible role of visfatin in these disorders. Patients with ANhad severely decreased body mass index (BMI) and body fatcontent. BMI of BN group did not significantly differ from that ofC group, whereas body fat content of BN group was significantlylower compared to C and higher compared to AN group,respectively. Serum glucose levels did not significantly differamong the groups studied, whereas serum insulin and leptinlevels and HOMA index were significantly decreased in AN grouprelative to both C and BN group. In contrast, serum visfatin levelsin both patients with AN and BN did not differ from those of Cgroup. We conclude that circulating visfatin levels are notaffected by the presence of chronic malnutrition in AN orbinge/purge eating behavior in BN.