Open AccessThe effects of 17β estradiol, 17α estradiol and progesterone on oxidative stress biomarkers in ovariectomized female rat brain subjected to global cerebral ischemia
Author(s) -
Ozacmak Vh,
Hale Sayan
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931647
Subject(s) - ovariectomized rat , neuroprotection , oxidative stress , endocrinology , medicine , malondialdehyde , ischemia , glutathione , hippocampus , striatum , antioxidant , hormone , estrogen , chemistry , biochemistry , dopamine , enzyme
Neuroprotective effects of estrogens and progesterone have beenwidely studied in various experimental models. The present studywas designed to compare possible neuroprotective effects of17alpha-estradiol, 17beta-estradiol, and progesterone onoxidative stress in rats subjected to global cerebral ischemia.Global cerebral ischemia was induced in ovariectomized femalerats by four vessel occlusion for 10 min. Following 72 h ofreperfusion, levels of malondialdehyde (MDA, oxidative stressmarker), and reduced glutathione (GSH, major endogenousantioxidant) were assessed in hippocampus, striatum and cortexof rats treated with either 17alpha-estradiol, 17beta-estradiol,progesterone or estradiol + progesterone beforehand. Steroidadministration ameliorated ischemia-induced decrease in GSHand increase in MDA levels. Our data offers additional evidencethat estrogens and progesterone or combination of two exert aremarkable neuroprotective effect reducing oxidative stress.