Open AccessSerum concentrations of adipocyte fatty acid binding protein in patients with anorexia nervosa
Author(s) -
D Haluzíková,
I Dostálová,
Petra Kaválková,
Tomáš Roubíček,
Miloš Mráz,
Hana Papežová,
Martin Haluzı́k
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931575
Subject(s) - medicine , endocrinology , leptin , adiponectin , resistin , triglyceride , insulin , metabolic syndrome , adipocyte , body mass index , obesity , anorexia nervosa , fatty acid binding protein , insulin resistance , adipose tissue , cholesterol , chemistry , eating disorders , biochemistry , psychiatry , gene
Serum adipocyte fatty acid-binding protein (FABP) concentrationsare linked to human obesity and other features of metabolicsyndrome. Whether FABP associates with metabolic alterations inchronic malnutrition is unknown. In the present study, wemeasured fasting serum levels of FABP, leptin, soluble leptinreceptor, adiponectin, resistin, C-reactive protein (CRP), insulin,glucose, cholesterol and triglycerides in 19 patients with arestrictive type of anorexia nervosa (AN) and in 16 healthy agematched control women (C). Body mass index, serum leptin, andCRP concentrations were significantly lower, while serumadiponectin and soluble leptin receptor levels were significantlyhigher in AN relative to C group. Serum insulin, glucose,cholesterol and triglyceride levels did not differ between thegroups studied. Serum FABP levels were unchanged in patientswith AN and were not related to any of parameters studied. Weconclude that, in contrast to patients with obesity where FAPB isa prominent marker of metabolic alterations, chronic malnutritionin AN does not significantly affect its serum levels.