Open AccessMechanism of action of homocysteine and its thiolactone in hemostasis system
Author(s) -
Kamil Karolczak,
Beata Olas
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931566
Subject(s) - homocysteine , hemostasis , thiolactone , fibrinogen , chemistry , platelet , biochemistry , hyperhomocysteinemia , medicine , pharmacology , stereochemistry
In the article, the actions of homocysteine (Hcys) and itsmetabolite - cyclic thioester – homocysteine thiolactone (HTL) oncomplex process of hemostasis, which regulates the flowingproperties of blood, are described. Possible interaction of Hcysand HTL with endothelial cells, blood platelets, plasmaticfibrinogen and plasminogen, as the important major componentsof hemostasis are also discussed. The modification of hemostaticproteins (N-homocysteinylated or S-homocysteinylated proteins)induced by Hcys or its thiolactone, and links of homocysteine orhomocysteine thiolactone to •NO metabolism seem to be themain reason of biotoxicty of homocysteine in cardiovasculardiseases.