Open AccessTime-course of tissue factor plasma level in patients with acute coronary syndrome
Author(s) -
Josef Bis,
Jan Vojáček,
Jiří Dušek,
M Pecka,
Vladimír Palička,
Josef Šťásek,
Jiří Malý
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931521
Subject(s) - acute coronary syndrome , medicine , scad , thrombosis , cardiology , tissue factor , coronary artery disease , coronary sinus , gastroenterology , myocardial infarction , coagulation
Enhanced expression of tissue factor (TF) may result inthrombosis contributing to acute clinical consequences ofcoronary artery disease. Several studies demonstrated elevatedplasma levels of TF in patients with acute coronary syndrome(ACS). The aim of our study was to compare the concentrationsof TF in coronary sinus (CS), proximal part of the left coronaryartery (LCA) and peripheral vein (PV) of patients with ACS andstable coronary artery disease (SCAD). Time course of the TFplasma levels in PV was followed on day 1 and day 7 after indexevent of ACS presentation and was compared to day 0 values. Noheparin was given prior to the blood sampling. Twenty-ninepatients in the ACS group (age 63.6±10.8 years, 20 males,9 females) and 24 patients with SCAD (age 62.3±8.1 years,21 males, 3 females) were examined. TF plasma level wassignificantly higher in patients with ACS than in those with SCAD(239.0±99.3 ng/ml vs. 164.3±114.2 ng/ml; p=0.016). There wasno difference in TF plasma levels in PV, CS and LCA (239.0± 99.3ng/ml vs. 253.7±131.5 ng/ml vs. 250.6±116.4 ng/ml,respectively). TF plasma levels tended to decrease only nonsignificantly on the day 7 (224.4±109.8 ng/ml). Significant linearcorrelation between TF and high sensitivity CRP (hs-CRP) levelson day 0 was found. In conclusion, TF plasma levels are elevatedin patients with ACS not only locally in CS but also in systematiccirculation. Our data support the relationship between TFproduction and proinflammatory mediators.