Open AccessEffects of endurance exercise training on markers of cholesterol absorption and synthesis
Author(s) -
Wilund Kr,
Feeney La,
Tomayko Ej,
Weiss Ep,
Hagberg Jm
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931515
Subject(s) - lathosterol , campesterol , medicine , endocrinology , cholesterol , metabolic syndrome , hyperlipidemia , desmosterol , endurance training , diabetes mellitus , obesity , chemistry , sterol
Abnormal cholesterol metabolism, including low intestinalcholesterol absorption and elevated synthesis, is prevalent indiabetes, obesity, hyperlipidemia, and the metabolic syndrome.Diet-induced weight loss improves cholesterol absorption in thesepopulations, but it is not known if endurance exercise trainingalso improves cholesterol homeostasis. To examine this, wemeasured circulating levels of campesterol, sitosterol, andlathosterol in 65 sedentary subjects (average age 59 years; withat least one metabolic syndrome risk factor) before and after6 months of endurance exercise training. Campesterol andsitosterol are plant sterols that correlate with intestinalcholesterol absorption, while lathosterol is a marker of wholebody cholesterol synthesis. Following the intervention, plantsterol levels were increased by 10 % (p<0.05), but there was nochange in plasma lathosterol. In addition, total and LDLcholesterol were reduced by 0.16 mmol and 0.10 mmol,respectively (p<0.05), while HDL-C levels increased by0.09 mmol (p<0.05). Furthermore, the change in plant sterolswas positively correlated with the change in VO2max (r = 0.310,p=0.004), independent of other metabolic syndrome risk factors.These data indicate that exercise training reduces plasmacholesterol despite increasing cholesterol absorption in subjectswith metabolic syndrome risk factors.