Open AccessRapid but not slow spinal cord compression elicits neurogenic pulmonary edema in the rat
Author(s) -
Jiří Šedý,
Josef Zicha,
Jaroslav Kuneš,
Pavla Jendelová,
Eva Syková
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931508
Subject(s) - medicine , edema , pulmonary edema , balloon , anesthesia , spinal cord , cord , circulatory system , cardiology , surgery , lung , psychiatry
The development of neurogenic pulmonary edema (NPE) can beelicited by an immediate epidural balloon compression of thethoracic spinal cord. To evaluate whether a slower ballooninflation could prevent NPE development, we examined theextent of NPE in animals lesioned with a rapid (5 μl - 5 μl - 5 μl)or slow rate (3 μl - 2 μl - 2 μl - 2 μl - 2 μl - 2 μl - 2 μl) of ballooninflation. These groups were compared with the NPE model(immediate inflation to 15 μl) and with healthy controls. Slowballoon inflation prevented NPE development, whereas thepulmonary index and histology revealed a massive pulmonaryedema in the group with a rapid rate of balloon inflation.Pulmonary edema was preceded by a considerable decrease inheart rate during the inflation procedure. Moreover, rapidinflation of balloon in spinal channel to either 5 μl or 10 μl did notcause NPE. Thus, a slow rate of balloon inflation in the thoracicepidural space prevents the development of neurogenicpulmonary edema, most likely due to the better adaptation of theorganism to acute circulatory changes (rapid elevation ofsystemic blood pressure accompanied by profound heart ratereduction) during the longer balloon inflation period. It should benoted that spinal cord transection at the same level did not causeneurogenic pulmonary edema.