Open AccessChange in Fatty Acid Composition of Serum Lipids in Obese Females after Short-Term Weight Reducing Regimen with the Addition of n-3 Long Chain Polyunsaturated Fatty Acids In Comparison To Controls
Author(s) -
P Hlavatý,
Marie Kunešová,
M Gojová,
E Tvrzická,
Marek Vecka,
Petr Roubal,
Martin Hill,
Karolína Hlavatá,
P Kalousková,
V Hainer,
Annissa Zak,
Jan Drbohlav
Publication year - 2008
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931490
Subject(s) - eicosapentaenoic acid , docosahexaenoic acid , polyunsaturated fatty acid , fish oil , fatty acid , regimen , food science , chemistry , composition (language) , biochemistry , low calorie diet , weight loss , endocrinology , biology , medicine , obesity , fish <actinopterygii> , linguistics , philosophy , fishery
Short-term weight-reducing regimens were shown to influence fatty acid composition of serum lipids unfavorably. Adding long chain n-3 polyunsaturated fatty acids (n-3 LC PUFA) to a low-calorie diet (LCD) could avoid these changes. The aim of this study was to examine the effect of a short-term in-patient weight-reducing regimen including LCD with yogurt enriched by low doses of n-3 PUFA (n-3 LCD). The enriched yogurt contained 790 mg of fish oil, predominantly eicosapentaenoic (20:5n-3; EPA) and docosahexaenoic (22:6n-3; DHA). Forty obese women were randomly assigned to the group consuming LCD and joghurt either with or without n-3 enrichment. Following the 3-week diet in the n-3 LCD group a significantly higher increase in the proportion of n-3 LC PUFA (sum of n-3 FA, EPA and DHA) in serum lipids was confirmed. In phospholipids (PL) a significant difference in the sum of n-6 fatty acids was found, a decrease in the n-3 LCD group and an increase in LCD group. Significantly higher increase in the PL palmitate (16:0) was shown in the LCD group. The results suggest that low doses of n-3 fatty acid enrichment can help to avoid unfavorable changes in fatty acid composition in serum lipids after a short-term weight-reducing regimen.