Open AccessThe effect of pheochromocytoma treatment on subclinical inflammation and endocrine function of adipose tissue
Author(s) -
Lenka Bošanská,
Ondřej Petrák,
Tomáš Zelinka,
Miloš Mráz,
Jiří Widimský,
Martin Haluzı́k
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931483
Subject(s) - medicine , pheochromocytoma , adiponectin , resistin , leptin , endocrinology , glycated hemoglobin , adipose tissue , blood pressure , subclinical infection , inflammation , diabetes mellitus , obesity , adipokine , type 2 diabetes , insulin resistance
The aim of our study was to evaluate the influence of surgicalremoval of pheochromocytoma on the endocrine function ofadipose tissue and subclinical inflammation as measured bycirculating C-reactive protein (CRP) levels. Eighteen patients withnewly diagnosed pheochromocytoma were included into study.Anthropometric measures, biochemical parameters, serum CRP,leptin, adiponectin and resistin levels were measured at the timeof diagnosis and six months after surgical removal ofpheochromocytoma. Surgical removal of pheochromocytomasignificantly increased body weight, decreased both systolic anddiastolic blood pressure, fasting blood glucose and glycatedhemoglobin levels. Serum CRP levels were decreased by 50 % sixmonths after surgical removal of pheochromocytoma (0.49±0.12vs. 0.23±0.05 mg/l, p<0.05) despite a significant increase inbody weight. Serum leptin, adiponectin and resistin levels werenot affected by the surgery. We conclude that increased bodyweight in patients after surgical removal of pheochromocytoma isaccompanied by an attenuation of subclinical inflammationprobably due to catecholamine normalization. We failed todemonstrate an involvement of the changes in circulating leptin,adiponectin or resistin levels in this process.