Open AccessSelected Adipokines - Plasma Concentrations and Adipose Tissue Expressions during 24-Hour Lipid Infusion in Healthy Men
Author(s) -
Jan Kopecký,
E. Krušinová,
Marta Klementová,
L Kazdová,
Petr Mlejnek,
Michal Pravenec,
Michael R. Hill,
T Pelikánová
Publication year - 2010
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931464
Subject(s) - resistin , adiponectin , medicine , endocrinology , adipokine , leptin , adipose tissue , triglyceride , plasma concentration , hyperlipidemia , adipocyte , hypertriglyceridemia , chemistry , insulin , cholesterol , obesity , insulin resistance , diabetes mellitus
Our aim was to assess the reaction of TNFα, resistin, leptin andadiponectin to lipid infusion. Eight healthy subjects underwent a24-hour lasting infusion of lipid emulsion. Plasma concentrationsand expressions of selected cytokines in subcutaneous fat weremeasured. TNFα plasma concentration did not change during thefirst 4 hours of hypertriglyceridemia, but a significant increaseafter 24 hours was detected (p<0.001 for 0; 30; 240 min vs.24 h). Plasma concentration of resistin significantly increased at30 min of infusion and remained elevated (p<0.01 for 0 min vs.30; 240 min; p<0.001 for 0 min vs. 24 h). Plasma concentrationsof leptin and adiponectin did not show any significant changes.Although the expression of resistin in the subcutaneous adiposetissue tended to increase, the change was not significant.Expressions of TNFα, leptin and adiponectin were unaffected. Inconclusions, our results indicate that acutely inducedhyperlipidemia could influence the secretion of TNFα and resistin.