Open AccessNatriuretic peptides – physiology, pathophysiology and clinical use in heart failure
Author(s) -
J Krupicka,
Tomáš Janota,
Z Kasalová,
J Hradec
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931461
Subject(s) - heart failure , medicine , natriuretic peptide , pathophysiology , cardiology , intensive care medicine , clinical trial , brain natriuretic peptide , bioinformatics , biology
The natriuretic peptides – atrial, brain and C-type – werediscovered during the last twenty years. Their effects oncardiovascular, renal, cerebral and other tissues through guanylylcyclase were uncovered. Over the past decade natriureticpeptides (NPs) became a very useful tool in the management ofheart failure patients. Results of many clinical trials have shownthat BNP and NT-proBNP are helpful for diagnosis of heartfailure. They are also independent markers of prognosis not onlyin heart failure patients but also in patients with othercardiovascular diseases. Recently published data document theutility of NPs in guiding treatment of heart failure patients. In thisarticle, we focus on basic biochemical and physiologicalcharacteristics of NPs as well as on their significance inmanagement of heart failure patients. Some limitations andpitfalls of NPs levels interpretation in diagnosing heart failure arealso discussed.