Open AccessRed wine polyphenols affect the collagen composition in the aorta after oxidative damage induced by chronic administration of CCl4.
Author(s) -
L. Hlavačková,
Pavol Janega,
Andrea Černá,
Oľga Pecháňová,
Ramaroson Andriantsitohaina,
Pavel Babál
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931435
Subject(s) - polyphenol , oxidative stress , chemistry , aorta , wine , ccl4 , oxidative phosphorylation , type i collagen , endothelium , medicine , pharmacology , endocrinology , biochemistry , antioxidant , food science , carbon tetrachloride , organic chemistry
Increased amount of collagen type I and decreased amount oftype III is described in various pathological processes in thevascular wall. Polyphenols were shown to have protective effecton endothelium, decrease blood pressure and prevent oxidativedamage induced by various stimuli. Tetrachlormethane (CCl4) is atoxic substance with known negative systemic effects induced byfree radicals. Chronic administration of CCl4 for 12 weeks led toan increase of collagen type I and a decrease of type III in thewall of aorta. Parallel administration of red wine polyphenolssignificantly reduced the increase of collagen type I, at the sametime the content of type III rose to the level above controls. After4 weeks of spontaneous recovery no changes were observed. Ifpolyphenols were administered during the recovery period, therewas a decrease of type I and an increase of type III collagencontent in the aorta. It can be concluded that polyphenols have atendency to lower the amount of type I and to increase theproportion of type III collagen in the wall of the aorta. Thesechanges are significant in prevention or in regression of changesinduced by chronic oxidative stress. This effect of polyphenols ismost likely the result of their influence on MMP-1 and TIMPactivities through which they positively influence the collagentypes I and III content ratio in the vascular wall in favor of thetype III collagen.