Open AccessMechanisms of neurogenic pulmonary edema development
Author(s) -
Jiří Šedý,
Josef Zicha,
Jaroslav Kuneš,
Pavla Jendelová,
Eva Syková
Publication year - 2008
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931432
Subject(s) - medicine , pulmonary edema , edema , pathophysiology , etiology , neurogenic inflammation , anesthesia , complication , central nervous system , pathology , lung , receptor , substance p , neuropeptide
Neurogenic pulmonary edema is a life-threatening complication,known for almost 100 years, but its etiopathogenesis is still notcompletely understood. This review summarizes currentknowledge about the etiology and pathophysiology of neurogenicpulmonary edema. The roles of systemic sympathetic discharge,central nervous system trigger zones, intracranial pressure,inflammation and anesthesia in the etiopathogenesis ofneurogenic pulmonary edema are considered in detail. Themanagement of the patient and experimental models ofneurogenic pulmonary edema are also discussed.