Open AccessSkin blood flowmotion and microvascular reactivity investigation in hypercholesterolemic patients without clinically manifest arterial diseases
Author(s) -
Marco Rossi,
Angelo Carpi,
C Di Maria,
Ferdinando Franzoni,
Fabio Galetta,
Gino Santoro
Publication year - 2009
Publication title -
physiological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 70
eISSN - 1802-9973
pISSN - 0862-8408
DOI - 10.33549/physiolres.931351
Subject(s) - laser doppler velocimetry , sodium nitroprusside , medicine , iontophoresis , forearm , endothelial dysfunction , vasodilation , cardiology , reactive hyperemia , arterial blood , endocrinology , blood flow , surgery , nitric oxide , radiology
Fourier spectral analysis of forearm skin laser Doppler flowmetry(LDF) signal was performed in fifteen hypercholesterolemicpatients (HP), without clinically manifest arterial diseases, and infifteen age-matched healthy control subjects (CS), in order toinvestigate skin blood flowmotion (SBF). The LDF frequencyintervals studied were: 0.01-1.6 Hz total spectrum, as well as0.01-0.02 Hz (endothelial), 0.02-0.06 Hz (sympathetic), 0.06-0.2Hz (myogenic), 0.2-0.6 Hz (respiratory) and 0.6-1.6 Hz (cardiac).Skin microvascular reactivity (MVR) to acetylcholine (ACh) and tosodium nitroprusside (SNP) iontophoresis was also investigated.HP showed a lower post-ACh increase in power spectral density(PSD) of the 0.01-0.02 Hz SBF subinterval compared to CS(1.80±1.73 PU2/Hz vs 3.59±1.78 PU2/Hz, respectively; p<0.005), while they did not differ in MVR from CS. In eleven HP the 0.01-0.02 Hz SBF subinterval showed a higher post-ACh PSD increase near to the statistical significance after 10 weeks of rosuvastatintherapy (10 mg/day) compared to pretreatment test (3.04±2.95PU2/Hz vs 1.91±1.94 PU2/Hz; p=0.07). The blunted post-AChincrease in PSD of the 0.01-0.02 Hz SBF subinterval in HPsuggests a skin endothelial dysfunction in these patients. ThisSBF abnormality showed a tendency to improve afterrosuvastatin therapy in eleven treated patients.